期刊
CURRENT PHARMACEUTICAL DESIGN
卷 9, 期 16, 页码 1325-1330出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612033454838
关键词
opioid peptide; gluten exorphin; Rubisco; antinociception; learning; memory; anxiolytic; antidepressant
Opioid peptides showing selectivity for 6 receptor have been isolated from enzymatic digests of plant proteins. Five peptides were derived from wheat gluten, and named gluten exorphins A5, A4, B5, B4 and C. Two opioid peptides were also released from spinach ribulose-bisphosphate-carboxylase/oxygenase (Rubisco), and named rubiscolins-5 and -6. Among them, gluten exorphin 5A (Gly-Tyr-Tyr-Pro-Thr) and rubiscolin-6 (Tyr-Pro-Leu-Asp-Leu-Phe) improved learning performance in step-through type passive avoidance test after post-training oral administration in mice at doses of 300 mg/kg and 100 mg/kg, respectively, which are smaller than those required for antinociceptive activity.
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