期刊
HYPERTENSION RESEARCH
卷 26, 期 11, 页码 923-927出版社
JAPANESE SOC HYPERTENSION CENT ACADEMIC SOC, PUBL OFFICE
DOI: 10.1291/hypres.26.923
关键词
catecholamine; catechol-O-methyltransferase; liver; membrane-bound
We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Here we examined the soluble (S-) and membrane-bound (MB-) COMT activities and COMT protein in the liver, kidney, and erythrocytes in both strains. Both the activities and the amounts of MB-COMT in the liver were lower in SHR than in WKY rats, but no such trend was found in the kidney or erythrocytes. Nor was such a trend observed in any of these three tissues for S-COMT. These results indicate that liver MB-COMT may be a relevant factor in blood pressure regulation in rats.
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