期刊
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
卷 132, 期 1, 页码 1-16出版社
ELSEVIER
DOI: 10.1016/S0166-6851(03)00211-1
关键词
Leishmania; major surface protease; GP63; biosynthesis; gene expression
资金
- FIC NIH HHS [TW01369, TW00985] Funding Source: Medline
- NIAID NIH HHS [AI32135, AI43050, AI44540, AI48822, T32 AI07511, T32 AI07343] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI048822, R01AI043050, T32AI007343, R01AI032135, R21AI032135, T32AI007511] Funding Source: NIH RePORTER
Leishmania sp. are digenetic protozoa that cause an estimated 1.5-2 million new cases of leishmaniasis per year worldwide. Among the molecular factors that contribute to Leishmania sp. virulence and pathogenesis is the major surface protease, alternately called MSP, GP63, leishmanolysin, EC3.4.24.36, and PSP, which is the most abundant surface protein of leishmania promastigotes. Recent studies using gene knockout, antisense RNA and overexpression mutants have demonstrated a role for MSP in resistance of promastigotes to complement-mediated lysis and either a direct or indirect role in receptor-mediated uptake of leishmania. The MSP gene clusters in different Leishmania sp. include multiple distinct MSPs that tend to fall into three classes, which can be distinguished by their sequences and by their differential expression in parasite life stages. Regulated expression of MSP class gene products during the parasite life cycle occurs at several levels involving both mRNA and protein metabolism. In this review we summarize advances in MSP research over the past decade, including organization of the gene families, crystal structure of the protein, regulation of mRNA and protein expression, biosynthesis and possible functions. The MSPs exquisitely demonstrate the multiple levels of post-transcriptional gene regulation that occur in Leishmania sp. and other trypanosomatid protozoa. (C) 2003 Elsevier B.V. All rights reserved.
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