期刊
EXPERIMENTAL GERONTOLOGY
卷 38, 期 11-12, 页码 1259-1264出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2003.09.015
关键词
senescence; telomeres; replicometer; stress; hayflick limit; fibroblast
The idea that aging is largely the result of (endogeneous) stress appears to be at odds with the concept of biological 'clocks', which seem to programme and terminate cellular aging processes. Here, data are reviewed that show that telomeres, the major clock identified in human cells so far, do in fact measure stress and damage accumulation much more than simple mitotic time. Telomere shortening is significantly stress-dependent due to a telomere-specific damage repair deficiency. This identifies telomere-driven human cell replicative senescence as a stress response with high potential importance for human aging. (C) 2003 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据