期刊
CELL CYCLE
卷 2, 期 4, 页码 307-309出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.2.4.435
关键词
origin licensing; Sic1; p27KIP; chromosome condensation; genome instability
类别
During the G(1) phase of the cell cycle, replication origins are prepared to fire, a process that is referred to as origin licensing. It was often pondered what a cell's fate would be if not all of its replication origins were licensed and subsequently activated during S phase. One obvious prediction was that S phase would simply be prolonged. As it turns out, however, the consequences are much more complex. A short G(1) phase enforced by premature entry into S phase, or other events that negatively affect origin licensing, will ultimately compromise the cell's ability to complete DNA replication before entering mitosis. As a result, the cell becomes genomically unstable when it attempts to repair unreplicated DNA during anaphase. Thus, the density of active replication origins in the chromosomes of eukaryotic cells determines S phase dynamics and chromosome stability during mitosis.
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