期刊
CHIMIA
卷 57, 期 11, 页码 731-734出版社
NEW SWISS CHEMICAL SOC
DOI: 10.2533/000942903777678641
关键词
agrochemicals; bioavailability; design guidelines; property profiles; 'rule of five'
This work provides a comprehensive overview of agrochemical properties in terms of the way they change during progression from screen hit to product and in terms of their limits as expressed in modern commercial products. Most herbicides and fungicides readily meet the Lipinski 'rule of five' criteria for drug-like compounds with many meeting the more constrained limits reported for pharmaceutical leads.
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