期刊
JOURNAL OF MEDICAL ENTOMOLOGY
卷 40, 期 1, 页码 78-81出版社
OXFORD UNIV PRESS INC
DOI: 10.1603/0022-2585-40.1.78
关键词
Ornithodoros moubata; midgut; hemoglobin fragment; antibacterial activity
Midgut contents of Ornithodoros monbata showed strong antibacterial activity against Staphylococcus aureus. A combination of reversed-phase chromatography and mass spectrometric analysis was used to isolate two antibacterial peptides from the tick midgut lumen. Partial amino acid sequences by Edman degradation of these two peptides showed they are identical with the 1-11 and 3-19 portions of rabbit a hemoglobin. Host rabbit a hemoglobin appears to be cleaved between Met(32) and Phe(33) to produce these two antibacterial peptides. Isolation of a host bovine hemoglobin fragment with antimicrobial activity has been demonstrated in the Ixodid tick, Boophilus microplus (Fogaca et al. 1999). Similar immune mechanisms in the two major families of ticks, Ixodidae and Argasidae, appear to use the hemoglobin of the host as an antimicrobial agent in midgut defense.
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