期刊
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
卷 86, 期 6, 页码 1014-1021出版社
WILEY
DOI: 10.1002/ccd.25754
关键词
near-infrared spectroscopy; lipid core plaque; acute coronary syndrome
资金
- Swedish Heart and Lung Foundation
- Swedish Scientific Research Council
- Frederik Meijer Heart & Vascular Institute, Spectrum Health
ObjectiveThis study was performed to assess the lipid burden of culprit lesions in non-ST-segment elevation myocardial infarction (non-STEMI) and unstable angina (UA). BackgroundA recent intracoronary near-infrared spectroscopy (NIRS) study showed 85% of STEMI culprit lesions have a maximum lipid core burden index in 4-mm (maxLCBI(4mm))400. Whether culprit lesions in non-STEMI and UA are characterized by a similarly large lipid burden is unknown. MethodsWe studied 81 non-STEMI and UA patients undergoing culprit vessel NIRS imaging before stenting. Culprit segments were compared to all nonoverlapping 10-mm nonculprit segments for maxLCBI(4mm). Culprit segments in non-STEMI and UA were compared for the frequency of maxLCBI(4mm)400. ResultsAmong 81 patients (53.1% non-STEMI, 46.9% UA), non-STEMI culprit segments had a 3.4-fold greater maxLCBI(4mm) than nonculprits (448229 vs 132 +/- 154, P<0.001) and UA culprit segments had a 2.6-fold higher maxLCBI(4mm) than nonculprits (381 +/- 239 vs 146 +/- 175, P<0.001). NIRS detected a maxLCBI(4mm)400 in 63.6% of culprit segments in NSTEMI and in 38.5% of culprit segments in UA (P=0.02). Against a background of nonculprit segments, maxLCBI(4mm)400 had a sensitivity of 63.6% and specificity of 94.0% for culprit segments in NSTEMI and a sensitivity of 38.5% and specificity of 89.8% for culprit segments in UA. ConclusionsLarge lipid cores similar to those recently detected by NIRS at STEMI culprit sites were frequently observed at culprit sites in patients with non-STEMI and UA. These findings support ongoing prospective trials designed to determine if NIRS can provide site-specific prediction of future acute coronary events. (c) 2014 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据