期刊
CELL DEATH AND DIFFERENTIATION
卷 10, 期 1, 页码 26-35出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cdd.4401186
关键词
TNF; DISC; apoptosis
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM061712] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM61712-01] Funding Source: Medline
CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tall. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. A number of proteins have been reported to regulate formation or activity of the DISC. This review discusses recent developments in this area of death receptor research.
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