期刊
MICROBES AND INFECTION
卷 5, 期 1, 页码 49-58出版社
ELSEVIER
DOI: 10.1016/S1286-4579(02)00055-2
关键词
neutrophils; chemotaxis; CD38; cyclic ADP-ribose; formyl peptide receptors
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI043629] Funding Source: NIH RePORTER
- NIAID NIH HHS [AI-43629] Funding Source: Medline
Through its production of cyclic adenosine diphosphate ribose, the ecto-enzyme CD38 regulates calcium mobilization in neutrophils responding to some, but not all, chemoattractants. This signaling defect results in reduced chemotaxis of CD38-deficient neutrophils to bacterial peptides and increased susceptibility of CD38-deficient mice to bacterial infections. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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