期刊
LUPUS
卷 12, 期 11, 页码 854-856出版社
ARNOLD, HODDER HEADLINE PLC
DOI: 10.1191/0961203303lu463cr
关键词
acquired haemophila; factor VIII inhibitors; lupus anticoagulant; monoclonal gammopathy
类别
Acquired haemophilia or factor VIII (FVIII) deficiency, caused by FVIII inhibitor antibodies, is a very rare condition that commonly results in severe haemorrhagic complications. We report a case of acquired haemophilia presenting with a left calf nontraumatic haematoma. The patient was also found to have lupus anticoagulant (LAC). The simultaneous presence of LAC and FVIII inhibitor is exceedingly rare. The differentiation between these two conditions is crucial, because both result in a prolongation of the activated partial thromboplastin time test, which does not correct when mixed with the plasma of a normal control; however, the clinical manifestations range from thrombosis in the presence of LAC to massive haernorrhage with FVIII inhibitors.
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