期刊
CELL CYCLE
卷 2, 期 6, 页码 528-530出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/cc.2.6.597
关键词
SUMO; Elk-1; TCFs; transcription repression; MAP kinase; ERK
类别
资金
- Wellcome Trust
- MRC and BBSRC
- Lister Institute of Preventive Medicine Research Fellowship
SUMO modification of proteins is being increasingly linked with transcriptional repression. We recently demonstrated that SUMO modification also downregulates the transcriptional activity of the ETS-domain transcription factor Elk-1. However, as Elk-1 becomes activated through MAP kinase-mediated phosphorylation, the SUMO modification is lost, providing an elegant molecular switch that promotes the loss of repressive activities at the same time as permitting the recruitment of coactivator proteins. However, the mechanism by which SUMO promotes transcriptional repression remains enigmatic.
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