期刊
MULTIPLE SCLEROSIS JOURNAL
卷 10, 期 5, 页码 556-561出版社
SAGE PUBLICATIONS LTD
DOI: 10.1191/1352458504ms1073oa
关键词
multiple sclerosis; relapsing-remitting; secondary progressive; T-1 relaxation time
In an attempt to clarify whether T-1 relaxation time mapping may assist in characterizing the pathological brain tissue substrate of multiple sclerosis (MS), we compared the T-1 relaxation times of lesions, areas of normal-appearing white matter (NAWM) located proximal to lesions, and areas of NAWM located distant from lesions in 12 patients with the relapsing - remitting and 12 with the secondary progressive (SP) subtype of disease. Nine healthy volunteers served as controls. Calculated mean T-1 values were averaged across all patients within each clinical group, and comparisons were made by means of the Mann - Whitney U-test. Significant differences were found between all investigated brain regions within each clinical subgroup. Significant differences were also detected for each investigated brain region among clinical subgroups. While T-1 values of NAWM were significantly higher in patients with SP disease than in normal white matter (NWM) of controls, no differences were detected when corresponding brain areas of patients with RR MS were compared with NWM of controls. T-1 maps identify areas of the brain that are damaged to a different extent in patients with MS, and may be of help in monitoring disease progression.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据