期刊
GENOME BIOLOGY
卷 5, 期 12, 页码 -出版社
BMC
DOI: 10.1186/gb-2004-5-12-r98
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资金
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG002779] Funding Source: NIH RePORTER
- NHGRI NIH HHS [R01 HG002779-05, R01 HG002779-04] Funding Source: Medline
We introduce a method (MONKEY) to identify conserved transcription-factor binding sites in multispecies alignments. MONKEY employs probabilistic models of factor specificity and binding-site evolution, on which basis we compute the likelihood that putative sites are conserved and assign statistical significance to each hit. Using genomes from the genus Saccharomyces, we illustrate how the significance of real sites increases with evolutionary distance and explore the relationship between conservation and function.
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