期刊
AIDS RESEARCH AND HUMAN RETROVIRUSES
卷 20, 期 1, 页码 111-126出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/088922204322749567
关键词
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资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI041420, R37AI036059, R01AI036554] Funding Source: NIH RePORTER
- NIAID NIH HHS [R37 AI036059, R01 AI41420, AI036554] Funding Source: Medline
In this review, we will discuss what is known, what is suspected, and what still remains obscure about the central role played by coreceptor expression and usage in the transmission and pathogenic consequences of human immunodeficiency virus type 1 (HIV-1) infection. An emphasis will be on the HIV-1 phenotypic variants that are defined by their usage of the CCR5 or CXCR4 coreceptors, and how the different cellular tropism of these variants influences how and where HIV-1 replicates in vivo. We will also review what might happen when coreceptor antagonists are used clinically to treat HIV-1 infection.
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