期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 8, 期 1, 页码 92-100出版社
AMER CHEMICAL SOC
DOI: 10.1021/op034130e
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The synthetic strategy for producing multigram quantities of (+)-discodermolide (1) using a hybridized Novartis-Smith-Paterson synthetic route via common precursor 3 is described. In the first part of this five-part series, we present a multikilogram preparation of alpha-methyl aldehyde 10 from Roche ester, its syn-aldol reaction with Evans boron enolate, removal of the chiral auxiliary, and the preparation of Weinreb amide 3 (Smith common precursor). The common precursor was produced without any chromatography.
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