期刊
CEREBROVASCULAR DISEASES
卷 18, 期 2, 页码 160-165出版社
KARGER
DOI: 10.1159/000079736
关键词
unstable plaque; carotid disease; neovascularization; vascular endothelial growth factor; matrix metalloproteinase 9
Background: The aim of this study was to evaluate the potential impact of vascular endothelial growth factor ( VEGF) on carotid plaque destabilization in association with matrix metalloproteinase 9 (MMP-9) production. Methods: Expression of VEGF and MMP-9 were determined immunohistochemically in 53 human endarterectomized atherosclerotic carotid plaques. The relationship to carotid plaque characteristics, clinical data and histological morphology was investigated. Results: VEGF and MMP-9 had parallel overexpression in the inflammatory cells, especially in the neovascularized plaque lesions and around the cholesterol crystals. Strong expression of VEGF was evident in symptomatic patients (p < 0.057), in high-degree stenosis (p = 0.005), and in patients with ischemic infarct in brain scan (p = 0.021). No relation was proved between molecule expression and plaque ultrasonic characteristics. Conclusions: An intense expression of VEGF and MMP-9 in carotid plaques is related to plaque instability, high degree of stenosis and presence of symptomatic carotid occlusive disease. Copyright (C) 2004 S. Karger AG, Basel.
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