Effects of a novel anti-hyperlipidemic agent, S-2E, on blood lipid levels in rats with fructose-induced hypertriglyceridemia

Using rats with fructose- induced hypertriglyceridemia, an animal model of human hypertriglyceridemia, we investigated whether (+)-( S)- p-[ 1-( p- tert- butylphenyl)- 2-oxo- 4- pyrrolidinyl]- methoxybenzoic acid ( S- 2E), a novel anti- hyperlipidemic agent, reduced the elevated levels of triglyceride ( TG) and non- high- density lipoprotein cholesterol ( non- HDL- C), and then whether it elevated HDL- C levels. At doses of 3 - 30 mg/ kg, S- 2E reduced elevated TG levels and non- HDL- C levels simultaneously in a dose-dependent manner after a week. Furthermore, S- 2E treatment at 10 mg/ kg for 4 weeks showed similar effects, while the elongation of intervals between feeding periods led to further increases in these levels. Interestingly, S- 2E increased blood HDL- C levels after 4 weeks of treatment. It is therefore reasonable to assume that S- 2E may be useful to improve dyslipidemia such as hypertriglyceridemia and low levels of HDL- C. Copyright (C) 2004 S. Karger AG, Basel.