期刊
JOURNAL OF EVOLUTIONARY BIOLOGY
卷 17, 期 1, 页码 55-66出版社
WILEY
DOI: 10.1046/j.1420-9101.2003.00652.x
关键词
decarboxylase; molecular clock; rates of evolution
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM042397] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM42397] Funding Source: Medline
The decarboxylases are involved in neurotransmitter synthesis in animals, and in pathways of secondary metabolism in plants. Different decarboxylase proteins are characterized for their different substrate specificities, but are encoded by homologous genes. We study, within a maximum-likelihood framework, the evolutionary relationships among dopa decarboxylase (Ddc), histidine decarboxylase (Hdc) and alpha-methyldopa hypersensitive (amd) in animals, and tryptophan decarboxylase (Wdc) and tyrosine decarboxylase (Ydc) in plants. The evolutionary rates are heterogeneous. There are differences between paralogous genes in the same lineages: 4.13 x 10(-10) nucleotide substitutions per site per year in mammalian Ddc vs. 1.95 in Hdc; between orthologous genes in different lineages, 7.62 in dipteran Ddc vs. 4.13 in mammalian Ddc; and very large temporal variations in some lineages, from 3.7 up to 54.9 in the Drosophila Ddc lineage. Our results are inconsistent with the molecular clock hypothesis.
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