Natural products for dengue transmission control - Larvicidal activity of Myroxylon balsamum (red oil) and of terpencids and phenylpropanoids

NATURAL PRODUCTS FOR DENGUE TRANSMISSION CONTROL- LARVICIDAL ACTIVITY OF Myroxylon balsamum (RED OIL) AND OF TERPENOIDS AND PHENYLPROPANOIDS. The bioassay-guided fractionation of the hexane extract obtained from the medicinal plant Myroxylon bolsamum (red oil) was conducted in preparative thin layer chromatography on silica gel. The obtained fractions and some terpenoids and phenylpropanoids were assayed as larvicidal on third instar Aedes aegypti larvae, NPPN colony. The results indicate that the sesquiterpene nerolidol was the active constituent in the extract and that the sesquiterpenes were more active than the monoterpenes and phenylpropanoids utilized in this study. Lipophilicity seems to be an important property for the activity since the compounds with hydroxyl, carbonyl and methoxyl groups were less active. The results confirm also that essential oils can be a good tool for the control of dengue.