期刊
INTERNATIONAL JOURNAL OF HEMATOLOGY
卷 79, 期 1, 页码 52-54出版社
SPRINGER JAPAN KK
DOI: 10.1007/BF02983534
关键词
diffuse large B-cell lymphoma; c-MYC; BCL2; BCL6; long-distance PCR
类别
We present a patient with stage III de novo diffuse large B-cell lymphoma. The lymphoma cells showed mature B-cell immunophenotype but lacked surface immunoglobulin (Ig) expression. Long-distance and long-distance inverse polymerase chain reaction assays to detect the oncogene/Ig gene rearrangement revealed that the cells carried 3 independent fusion genes, namely, c-MYC/Ig heavy chain gene (IgH), BCL2/IgH, and Ig lambda light chain gene/BCL6. Thus, the lymphoma cells concurrently carried t(8;14)(q24;q32), t(14;18)(q32;q21), and t(3;22)(q27;q11), which developed in association with class switching, V/D/J recombination, and somatic hypermutation, respectively. The lymphoma responded to chemoradiotherapy, and the patient has been well for 2 years, suggesting that multiple oncogene rearrangements may not necessarily be associated with poor clinical outcome. (C) 2004 The Japanese Society of Hematology.
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