期刊
INFLAMMATORY BOWEL DISEASES
卷 10, 期 1, 页码 28-31出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00054725-200401000-00004
关键词
Crohn's disease; infliximab; demyelinating disorder; tumor necrosis factor alpha
Background: Inflammatory demyelinating disease of the central nervous system may be linked to anti-tumor necrosis factor alpha therapy. Case history: A 19-year-old female with Crohn's ileocolitis developed right arm and leg numbness and right hand weakness 4 weeks after the initiation of infliximab. Neurologic examination confirmed upper and lower right extremity sensory and motor deficits. MRI examination of the head and thoracic cord showed multiple gadolinium-enhancing lesions with distribution and configuration most suggestive of multiple sclerosis or other demyelinating process. The infliximab therapy was immediately stopped and follow-up at 8 weeks revealed symptomatic improvement. Conclusion: This case report describes the onset of a demyelinating process after the institution of infliximab therapy in a patient with Crohn's disease.
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