期刊
CHEMISTRY & BIODIVERSITY
卷 1, 期 11, 页码 1702-1707出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.200490128
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Two novel labdane-type diterpenoids, butanedioic acid mono[ (13S)-13-hydroxylabda-8(17),14-dien-19-yl] ester (1) and butanedioic acid bis[(13S)-13-hydroxylabda-8(17),14-dien-19-yl] ester (2), along with the eleven known diterpenoids 3-13 and three other known compounds, were isolated from the bark of Larix chinensis. Their structures were elucidated both spectroscopically and chemically. The major diterpenoids 1 - 9, 11, and 13, as well as the very abundant phenolic compound 16, were subjected to antibacterial and cytotoxic bioassays. Compounds 7 and 9 showed remarkable in vitro inhibition of Staphylococcus aureus and S. epidermidis (MIC 37 - 73 mum).
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