期刊
PHOTOSYNTHESIS RESEARCH
卷 81, 期 3, 页码 251-275出版社
SPRINGER
DOI: 10.1023/B:PRES.0000036888.18223.0e
关键词
cytochrome bc(1); electron transport; photosynthesis; respiration; X-ray structure
资金
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM038237] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM038237] Funding Source: Medline
Ubihydroquinone: cytochrome (cyt) c oxidoreductase, or cyt bc(1), is a widespread, membrane integral enzyme that plays a crucial role during photosynthesis and respiration. It is one of the major contributors of the electrochemical proton gradient, which is subsequently used for ATP synthesis. The simplest form of the cyt bc(1) is found in bacteria, and it contains only the three ubiquitously conserved catalytic subunits: the Fe-S protein, cyt b and cyt c(1). Here we present a preliminary X-ray structure of Rhodobacter capsulatus cyt bc1 at 3.8 Angstrom and compare it to the available structures of its homologues from mitochondria and chloroplast. Using the bacterial enzyme structure, we highlight the structural similarities and differences that are found among the three catalytic subunits between the members of this family of enzymes. In addition, we discuss the locations of currently known critical mutations, and their implications in terms of the cyt bc(1) catalysis.
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