期刊
EUROPEAN NEUROLOGY
卷 52, 期 2, 页码 73-76出版社
KARGER
DOI: 10.1159/000079749
关键词
hypocretin; orexin; hypersomnia; dementia with Lewy bodies; excessive daytime sleepiness; narcolepsy; hallucinations; REM sleep behavior disorder; Alzheimer's disease
Excessive daytime sleepiness, hallucinations and REM sleep behavior disorder are symptoms reported in both dementia with Lewy bodies (DLB) and narcolepsy. Considering the demonstration of low hypocretin-1/orexin A levels in the cerebrospinal fluid (CSF) of most patients with narcolepsy, we hypothesized the presence of a deficient hypocretinergic transmission in DLB. Hypocretin-1 was tested in the CSF of 10 DLB patients. Levels were found to be in the normal range ( mean 521 pg/ml, range 382 - 667) when compared to controls (n = 20, mean 497 pg/ml, range 350 - 603) and Alzheimer's disease patients ( n = 7, mean 474 pg/ml, range 333 - 564). In DLB, excessive daytime sleepiness, hallucinations and REM sleep behavior may occur in the absence of a detectable hypocretin deficiency. Copyright (C) 2004 S. Karger AG, Basel.
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