期刊
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
卷 79, 期 4, 页码 654-658出版社
WILEY
DOI: 10.1002/ccd.23354
关键词
animal model; biomaterials; heart valve (transapical; percutaneous); off-pump surgery; pulmonary valve
资金
- Carag AG (Baar, Switzerland)
Objectives: This study evaluated the feasibility of inserting a new equine stented-valve with a sinus portion in a lamb survival model, through a minimally invasive thoracotomy with right ventricular access without cardiopulmonary bypass. Background: Extant surgical or percutaneous methods for inserting biological valves in the right outflow tract have drawbacks and limitations. Methods: A decellularized equine valved jugular vein, sutured to a self-expanding stent with a sinus portion, was placed through a minimal right thoracotomy using a newly developed flexible hydraulic release device in seven lambs. The approach through the right ventricle into the pulmonary valve position is achieved on a beating heart. Results: The stented valves were correctly positioned in the right outflow tract, were competent up to 6 months as confirmed by angiography and echocardiography, and were well-tolerated by the animals, with endothelialization of the valve demonstrated at 6 months. Conclusions: The newly developed hydraulic release system allowed for safe and reliable insertion of an equine stented-valve with a sinus portion, through a right transventricular approach on a beating heart, in a sheep survival model. (c) 2011 Wiley Periodicals, Inc.
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