期刊
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
卷 80, 期 3, 页码 429-436出版社
WILEY
DOI: 10.1002/ccd.23407
关键词
drug-eluting stent; polymer; biolimus A9; neointima
资金
- Biotronik
- Medtronic
- Boston Scientific
- Medicines Co.
- GlaxoSmithKline
- Schering-Plough
- Sanofi-Aventis
- 3F Therapeutics
- Abbott Vascular
- Amaranth Medical, Inc.
- Apnex Medical
- Ardian, Inc.
- Atrium Medical Corporation
- CardioDex, Ltd.
- CardioKinetix, Inc.
- CorAssist Cardiovascular, Ltd.
- Cordis Corporation
- Devax, Inc.
- ev3
- Gardia Medical, Ltd.
- HemCon
- Lutonix, Inc.
- Medtronic Vascular
- Meril Life Sciences Pvt, Ltd.
- Microvention, Inc.
- Novartis Pharmaceuticals Corporation
- NovoStent Corporation
- Oregon Medical Laser Center
- Prescient Medical, Inc.
- Relisys Medical Devices Limited
- Vascular Therapies, LLC
- Xtent, Inc.
Objectives: To evaluate the effect of a polymer-free Biolimus A9-eluting stent [BioFreedom (TM) (BF)], compared with that of a biodegradable polymer-based Biolimus A9-eluting stent [BioMatrix Flex (TM) (BMF)] and a bare metal stent (BMS) in balloon denuded and radiated hypercholesterolemic rabbit iliac arteries. Methods: Rabbits were fed with 1% cholesterol diet (n = 14) for 14 days, both iliac arteries were balloon denuded and radiated, and then rabbits were switched to 0.15% cholesterol diet. After 4 weeks, BF (n = 8), BMF (n = 8), and BMS (n = 8) were deployed in denuded and radiated areas. Four weeks later animals were euthanized, arterial segments were processed for morphometry. Results: The neointimal area in vessels implanted with BF stents was significantly less than that seen in vessels implanted with BMS (0.90 mm2 +/- 0.14 vs. 1.29 mm2 +/- 0.23, P <0.01). Percent fibrin and fibrin score were higher with BMF stents compared to BMS (P <0.03 and <0.04) and giant cell number was significantly higher with both BMF and BF stents (P < 0.01 for both). Percent endothelialization was significantly higher and % uncovered struts were lower with BMS compared to either BMF or BF stents (P < 0.05 for both). Conclusion: This study demonstrates that compared to BMS, BF stents significantly decreased neointimal hyperplasia. (c) 2011 Wiley Periodicals, Inc.
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