期刊
CHIMIA
卷 58, 期 9, 页码 630-633出版社
SWISS CHEMICAL SOC
DOI: 10.2533/000942904777677579
关键词
neurodegeneration; NMDA; NR1/2B antagonists; structure-activity relationship
A series of 2-styryl-pyridines and 2-(3,4-dihydro-naphthalen-2-yl)-pyridines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. The SAR developed in this series resulted in the discovery of high affinity antagonists that are selective (vs. alpha(1) and M-1 receptors) and are active in vivo.
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