期刊
JOURNAL OF ORTHOPAEDIC SCIENCE
卷 9, 期 4, 页码 410-414出版社
ELSEVIER
DOI: 10.1007/s00776-004-0786-3
关键词
osteogenesis; endochondral bone formation; intramembranous bone formation; hypertrophic chondrocytes; Indian hedgehog
类别
Mammalian bones have three distinct origins (paraxial mesoderm, lateral plate mesoderm, and neural crest) and undergo two different modes of formation (intramembranous and endochondral). Bones derived from the paraxial mesoderm and lateral plate mesoderm mainly form through the endochondral process. During this process, hypertrophic chondrocytes play a vital role in inducing both osteogenesis and angiogenesis. One of the essential osteogenic factors secreted from hypertrophic chondrocytes is Indian hedgehog (Ihh). In contrast, bones derived from the neural crest mainly form through the intramembranous process and do not require Ihh. Thus, depending on their origin, bones have distinct signaling properties, which need to be considered in the research and application of bone biology.
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