期刊
GENE EXPRESSION PATTERNS
卷 4, 期 1, 页码 99-103出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/S1567-133X(03)00142-X
关键词
mouse embryo; Rig-1; Robo1/DUTT1; spinal cord
The Robo genes encode a family of proteins that are the receptors for the midline repellent Slits and play a role in axon guidance. In addition to Robo1 and Robo2, Rig-1 has been recently identified in mouse as a novel member of the Robo1 family of proteins. As a first step in elucidating the role of Rig-1 during vertebrate development, we characterised the expression of Rig-1 by in situ hybridisation together with Robo1 and Robo2 in the spinal cord and other tissues of the mouse embryo. Our results show that Rig-1 has a dynamic pattern of expression in the developing CNS. In the spinal cord Rig-1 shows overlapping but distinct pattern of expression with Robo1 and Robo2. (C) 2003 Elsevier B.V. All rights reserved.
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