期刊
TRENDS IN GENETICS
卷 20, 期 1, 页码 1-4出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2003.11.001
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资金
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [P30AR046026] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067842, R01GM062516] Funding Source: NIH RePORTER
- NIAMS NIH HHS [AR-46026] Funding Source: Medline
- NIGMS NIH HHS [R01 GM062516-03, GM-62516, R01 GM067842-03, GM-67842] Funding Source: Medline
Ten percent of the human genome is composed of highly repetitive DNA sequences called AN elements. It has recently been found that at least 5% of all human alternative exons are derived from AN elements. Moreover, single nucleotide mutations can convert either alternative or otherwise silent AN elements into constitutive exons and this can lead to the development of human disease. These results provide new insights into the function and dangers of 'junk DNA' in the human genome.
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