期刊
MECHANISMS OF DEVELOPMENT
卷 121, 期 1, 页码 37-49出版社
ELSEVIER
DOI: 10.1016/j.mod.2003.11.002
关键词
Drosophila melanogaster; grainy head; Frizzled pathway; planar polarity
资金
- NIGMS NIH HHS [R01 GM037163] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM037163] Funding Source: NIH RePORTER
The Drosophila wing is covered by an array of distally pointing hairs. This tissue planar polarity is regulated by the frizzled pathway. We have found that the function of the grainy head transcription factor is essential for the function of the frizzled pathway. grainy head mutant cells fail to localize planar polarity proteins at either the proximal or distal sides of wing cells and produce multiple hairs of abnormal polarity. Levels of the Starry night protein are strongly reduced in grainy head mutants in both larval wing discs and pupal wings, which is sufficient to account for much of the polarity phenotype. In addition, we found that grh has frizzled pathway independent functions during the development of the adult cuticle. (C) 2003 Published by Elsevier Ireland Ltd.
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