期刊
MICROBIOLOGY AND IMMUNOLOGY
卷 48, 期 3, 页码 147-154出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1348-0421.2004.tb03500.x
关键词
innate immunity; toll-like receptor; type I interferon; anti-viral immunity; double-stranded RNA
Production of type I interferon (IFN-alpha/beta) by virus-infected cells is the central event in their antiviral immune responses. In mammalian cells, IFN-alpha/beta gene transcription is induced through distinct signaling pathways by viral infection or by treatment with double-stranded (ds) RNA, which is an intermediate of virus replication. Toll-like receptor 3 (TLR3) was found to recognize dsRNA and transmit signals to activate NF-kappaB and the IFN-beta promoter. Recent identification of the TLR3-adaptor protein and its downstream signaling molecules, which are involved in IFN-alpha/beta production, revealed a novel IFN-inducing pathway for an anti-viral immune response. Here, we summarize the current knowledge of TLR3-mediated immune responses.
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