期刊
MECHANISMS OF DEVELOPMENT
卷 121, 期 1, 页码 91-99出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2003.09.007
关键词
mammary development; alpha-catenin; WAP-Cre; MMTV-Cre; conditional deletion
资金
- NIAMS NIH HHS [R01 AR027883-29] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [Z01BC010021] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR027883] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [Z01DK061000] Funding Source: NIH RePORTER
Alpha-catenin is a structural molecule and essential to the function of epithelial adherents junctions. Its role in the morphogenesis of mammary epithelium was explored using experimental mouse genetics. Since loss of alpha-catenin in mice leads to embryonic lethality, the a.-catenin gene was flanked by loxP sites and inactivated in mammary epithelium using the WAP-Cre and MMTV-Cre transgenes. Loss of a-catenin arrested alveolar epithelial expansion. These cells lacked proper polarity and markers of functional differentiation, which resulted in impaired milk protein gene expression. Without alpha-catenin, increased epithelial cell death was observed at parturition and the tissue resembled an involuted gland that is normally observed after weaning. Lastly, no tumors were detected in mammary tissue lacking a-catenin. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
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