期刊
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
卷 134, 期 1, 页码 65-78出版社
KARGER
DOI: 10.1159/000078339
关键词
Tec family kinases; signaling; protein tyrosine kinases; myeloid cells; hematopoiesis; X-linked agammaglobulinemia; knockout mice
资金
- Austrian Science Fund FWF [Y 163] Funding Source: Medline
Members of the Tec kinase family (Bmx, Btk, Itk, Rlk and Tec) are primarily expressed in the hematopoietic system and form, after the Src kinase family, the second largest class of non-receptor protein tyrosine kinases. During lymphocyte development and activation Tec kinases have important functions in signaling pathways downstream of the antigen receptors. Tec family kinases are also expressed in cells of the myeloid lineage. However, with the exception of mast cells and platelets, their biological role in the myeloid system is only poorly understood. This review summarizes the current knowledge about the function of Tec family kinases in hematopoietic cells of the myeloid lineage. Copyright (C) 2004 S. Karger AG, Basel.
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