期刊
ACS CHEMICAL BIOLOGY
卷 10, 期 7, 页码 1610-1615出版社
AMER CHEMICAL SOC
DOI: 10.1021/cb5009734
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资金
- National Natural Science Foundation of China [21225206, 91313301, 21432002]
- National Key Basic Research Foundation of China [2011CB809103]
- National Science Foundation [CHE-1213598]
- Howard Hughes Medical Institute
Heme plays pivotal roles in various cellular processes as well as in iron homeostasis in living systems. Here, we report a genetically encoded fluorescence resonance energy transfer (FRET) sensor for selective heme imaging by employing a pair of bacterial heme transfer chaperones as the sensory components. This heme-specific probe allows spatial-temporal visualization of intracellular heme distribution within living cells.
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