Mitoxantrone - A review of its use in multiple sclerosis

Sources: Medical literature published in any language since 1680 on mitoxantrone, identified using Medline and EMBASE, supplemented by AdisBase (a proprietary database of Adis International). Additional references were identified from the, reference lists of published articles. Bibliographical information, including contributory unpublished data, was also requested from the company developing the drug. Search strategy: Medline, and AdisBase search terms were mitoxantrone and multiple-sclerosis': EMBASE: search terms were 'mitoxantrone'. Searches were last updated 20 March 2004 Selection: Studies in patients with multiple sclerosis who received mitoxantrone: Inclusion of studies was based mainly on the methods section of the trials. When available, large, well controlled trials with appropriate statistical methodology were preferred. Relevant pharmacodynamic and pharmacokinetic data are also included.