期刊
JOURNAL OF EXPERIMENTAL BIOLOGY
卷 218, 期 9, 页码 1433-1443出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/jeb.118299
关键词
Locomotion initiation; Optomotor response; Zebrafish
类别
资金
- Human Frontier Science Program [LT01115/2007-C]
- EMBO Long Term Postdoctoral fellowship [ALTF 1056-10]
- Jane Coffin Childs Fund for Biomedical Research
- National Institutes of Health [DP1-NS082121, R01-DA030304]
Caudo-rostral whole-field visual motion elicits forward locomotion in many organisms, including larval zebrafish. Here, we investigate the dependence on the latency to initiate this forward swimming as a function of the speed of the visual motion. We show that latency is highly dependent on speed for slow speeds (< 10 mm s(-1)) and then plateaus for higher values. Typical latencies are > 1.5 s, which is much longer than neuronal transduction processes. What mechanisms underlie these long latencies? We propose two alternative, biologically inspired models that could account for this latency to initiate swimming: an integrate and fire model, which is history dependent, and a stochastic Poisson model, which has no history dependence. We use these models to predict the behavior of larvae when presented with whole-field motion of varying speed and find that the stochastic process shows better agreement with the experimental data. Finally, we discuss possible neuronal implementations of these models.
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