期刊
ANNALS OF MEDICINE
卷 36, 期 4, 页码 252-261出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/07853890410028429
关键词
adiposity; DGAT; energy metabolism; insulin resistance; lipids; lipotoxicity; triglyceride synthesis
资金
- NHLBI NIH HHS [R01 HL73030, R01 HL55638] Funding Source: Medline
- NIDDK NIH HHS [K08-DK60530] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL073030, R01HL055638] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [K08DK060530] Funding Source: NIH RePORTER
Acyl-CoA:diacylglycerol acyltransferase (DGAT, EC2.3.1.20), a key enzyme in triglyceride (TG) biosynthesis, not only participates in lipid metabolism but also influences metabolic pathways of other fuel molecules. Changes in the expression and/or activity levels of DGAT may lead to changes in systemic insulin sensitivity and energy homeostasis. The synthetic role of DGAT in adipose tissue, the liver. and the intestine, sites where endogenous levels of DGAT activity and TG synthesis are high, is relatively clear. Less clear is whether DGAT plays a mediating or preventive role in the development of ectopic lipotoxicity in tissues such as muscle and the pancreas, when their supply of free fatty acids (FFAs) exceeds their needs. Future studies with tissue-specific overexpression and/or knockout in these animal models would be expected to shed additional light on these issues.
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