期刊
IMMUNOLOGIC RESEARCH
卷 30, 期 3, 页码 261-277出版社
HUMANA PRESS INC
DOI: 10.1385/IR:30:3:261
关键词
C-reactive protein; acute-phase response; pentraxins; autoimmune mice; inflammation; Fc receptors; LPS; SLE; complement
类别
资金
- NIAID NIH HHS [AI28358] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R29AI028358, R01AI028358] Funding Source: NIH RePORTER
C-reactive protein (CRP) is an acute-phase serum protein and a member of the pentraxin protein family. Its host defense functions predate the adaptive immune system by millions of years. Our current understanding of CRP interactions with complement and with Fcy receptors (FcgammaR) have led to an increased appreciation of the regulatory role of CRP in inflammation and autoimmunity. This review outlines the role of CRP in infection, inflammation, and autoimmune disease. We provide a description of recent studies, which suggest that CRP acts through FcgammaR to reduce inflammation and protect from certain autoimmune diseases. A general description of the proposed function of CRP is provided as a framework for future investigation.
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