期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 27, 期 8, 页码 729-737出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2003.11.008
关键词
chronic pain; descending facilitation; descending inhibition; periaqueductal gray; rostroventral medulla; nucleus raphe magnus
资金
- NATIONAL INSTITUTE ON DRUG ABUSE [R37DA002879, R01DA002879] Funding Source: NIH RePORTER
- NIDA NIH HHS [DA 02879] Funding Source: Medline
Although interest in descending modulation of spinal cord function dates back to the time of Sherrington, the modem era began in the late 1960s when it was shown that focal electrical stimulation in the midbrain of the rat produced analgesia sufficient to permit surgery. From this report evolved the concept of endogenous systems of pain modulation. Initial interest focused on descending inhibition of spinal nociceptive processing, but we now know that descending modulation of spinal nociceptive processing can be either inhibitory or facilitatory. As our understanding of descending facilitatory, or pro-nociceptive influences grows, so too has our appreciation of its potential importance. Accumulating evidence suggests that descending facilitatory influences may contribute to the development and maintenance of hyperalgesia and thus contribute to chronic pain states. (C) 2003 Elsevier Ltd. All rights reserved.
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