期刊
GLYCOCONJUGATE JOURNAL
卷 21, 期 1-2, 页码 17-24出版社
SPRINGER
DOI: 10.1023/B:GLYC.0000043742.99482.01
关键词
glycogene; glycogene project; glycosyltransferase; sulfotransferase; sugar-nucleotide transporter
Eighteen years have passed after the first mammalian glycosyltransferase was cloned. At the beginning of April, 2001, 110 genes for human glycosyltransferases, including modifying enzymes for carbohydrate chains such as sulfotransferases, had been cloned and analyzed. We started the Glycogene Project (GG project) in April 2001, a comprehensive study on human glycogenes with the aid of bioinformatic technology. The term glycogene includes the genes for glycosyltransferases, sulfotransferases adding sulfate to carbohydrates and sugar-nucleotide transporters, etc. Firstly, as many novel genes, which are the candidates for glycogenes, as possible were searched using bioinformatic technology in databases. They were then cloned and expressed in various expression systems to detect the activity for carbohydrate synthesis. Their substrate specificity was determined using various acceptors.
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