Comparative testing of 5 nicotine systems: Initial use and preferences

Objective: To test initial reactions to 5 nicotine treatments (NRTs: 2 and 4 mg gum, inhaler, nasal spray, tablet) in a crossover study (n=41). Methods: Subjects used each medication on arising ((1)/(2) day) and resumed smoking each afternoon. Subjects rated (individually) and ranked(comparatively) treatments on use, reinforcement, withdrawal, craving, and preferences. Results: Overall preferences: inhaler (49%), 4 mg gum (24%), 2 mg gum (10%), 2 mg tablet (10%), nasal spray (7%). Overall results were consistent with ratings and rankings of individual characteristics of drugs. Conclusion: Subjects had varied reactions to NRTs that may affect initiation of cessation.