期刊
GLYCOCONJUGATE JOURNAL
卷 21, 期 1-2, 页码 79-84出版社
SPRINGER
DOI: 10.1023/B:GLYC.0000043753.11090.88
关键词
mannan-binding protein; polymorphonuclear leukocytes; superoxide; platelet activation factor; polyvinyl-mannose
Mannan-binding protein (MBP) is a Ca2+-dependent mammalian lectin that plays an important role in innate immunity. In this study, we found that ligand-bound MBP stimulates polymorphonuclear leukocytes (PMN) to induce cell aggregation and superoxide production. The biological response of PMN to ligand-bound MBP was dose- and time-dependent. The PMN aggregation and superoxide production induced by ligand-bound MBP was blocked completely by pertussis toxin, and partially blocked by a platelet activation factor receptor antagonist, TCV-309. These findings suggest that the ligand-bound MBP stimulates PMN through a putative MBP receptor(s) on PMN.
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