期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 38, 期 1, 页码 3-15出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0022-3956(03)00096-7
关键词
mood disorder; psychosis; bipolar gene; depression; review
类别
资金
- NIMH NIH HHS [5 U01 MH46318-02, 1 R37MH43518-01, 1 R01MH41879-01] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH041879, R37MH043518, U01MH046318] Funding Source: NIH RePORTER
This article presents a conceptual review of the genetic underpinnings of psychotic mood disorders. Both unipolar and bipolar forms of mood disorder sometimes feature psychotic symptoms. Some evidence from epidemiological research suggests that psychotic forms of mood disorder specifically might be heritable. Linkage studies of mood disorders in general have also provided some support for that notion, as have associated studies involving serotonin and dopamine genes and psychotic mood disorder. Some research suggests there might be a genetic connection between schizophrenia and bipolar disorder, undermining the Kraepelinian dichotomous classification of the psychoses. Future research should continue to examine psychotic forms of mood disorder using both epidemiological and molecular approaches. (C) 2003 Published by Elsevier Ltd.
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