期刊
ACS CHEMICAL BIOLOGY
卷 11, 期 1, 页码 104-112出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschembio.5b00537
关键词
-
资金
- Department of Science and Technology, Government of India [DST/INT/Spain/P-30/11]
- CSIR-National Institute for Interdisciplinary Science and Technology [CSC 0134, BSC 0112]
- Spanish Ministerio de Economia y Competitividad [MINECO: PRI-PIBIN-2011-1011, SAF 2012-33404]
- Instituto de Salud Carlos III [TerCel RD12/0019/0004]
We synthesized novel tetraphenylethene (TPE) conjugates, which undergo unique self-assembly to form spherical nanoparticles that exhibited aggregation induced emission (AIE) in the near-infrared region. These nanoparticles showed significant singlet oxygen generation efficiency, negligible dark toxicity, rapid cellular uptake, efficient localization in cytoplasm, and high in vitro photocytotoxicity as well as in vivo photodynamic activity against a human prostate tumor animal model. This study demonstrates, for the first time, the power of the self-assembled AIE active tetraphenylethene conjugates in aqueous media as a nanoplatform for future therapeutic applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据