期刊
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY
卷 8, 期 6, 页码 327-332出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejpn.2004.08.005
关键词
tuberous sclerosis complex; autism; cortical tubers; infantile spasms
Despite considerable progress in the last few years, the neurobiologic basis of autism in tuberous sclerosis complex is still largely unknown and its clinical management represents a major challenge for child neurologists. Recent evidence suggests that early-onset refractory epilepsy and functional deficits associated with the anatomical lesions in the temporal lobes may be associated with autism. No one factor atone (cognitive impairment, tuber localization, occurrence of infantile spasms, focal EEG abnormalities), can be causally linked with the abnormal behaviour. Autism may also reflect a direct effect of the abnormal genetic program. Incidence of autism associated with Tuberous Sclerosis may be significantly higher than the rates of cardiac and renal abnormalities, for which screening is routinely conducted in this population. Hopefully, early diagnosis of autism will allow for earlier treatment and the potential for better outcome for children with Tuberous Sclerosis. (C) 2004 Published by Elsevier Ltd on behalf of European Paediatric Neurology Society.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据