期刊
ANNUAL REVIEW OF IMMUNOLOGY
卷 22, 期 -, 页码 563-598出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.immunol.22.012703.104721
关键词
I-phosphatidylinositol 3-kinase; PI3K; second messengers; signal transduction; lymphocyte activation
类别
资金
- NIAID NIH HHS [AI50831] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI050831] Funding Source: NIH RePORTER
Cells of the immune system carry out diverse functions that are controlled by surface receptors for antigen, costimulatory molecules, cytokines, chemokines, and other ligands. A shared feature of signal transduction downstream of most receptors on immune cells, as in nonhematopoietic cell types, is the activation of phosphoinositide 3-kinase (PI3K). The mechanism by which this common signaling event is elicited by distinct receptors and contributes to unique functional outcomes is an intriguing puzzle. Understanding how specificity is achieved in PI3K signaling is of particular significance because altered regulation of this pathway is observed in many disease states, including leukemia and lymphoma. Here we review recent advances in the understanding of PI3K signaling mechanisms in different immune cells and receptor systems. We emphasize the concept that PI3K and its products are components of complex networks of interacting proteins and second messengers, rather than simple links in linear signaling cascades.
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