期刊
ANNUAL REVIEW OF BIOCHEMISTRY
卷 73, 期 -, 页码 539-557出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev.biochem.73.011303.074048
关键词
SRP; signal sequence; SRP54; SRP19; SRP receptor; SRP RNA
资金
- NIGMS NIH HHS [GM 22778] Funding Source: Medline
The signal recognition particle (SRP) directs integral membrane and secretory proteins to the cellular protein translocation machinery during translation. The SRP is an evolutionarily conserved RNA-protein complex whose activities are regulated by GTP hydrolysis. Recent structural investigations of SRP functional domains and interactions provide new insights into the mechanisms of SRP activity in all cells, leading toward a comprehensive understanding of protein trafficking by this elegant pathway.
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