期刊
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
卷 30, 期 4, 页码 765-782出版社
MARCEL DEKKER INC
DOI: 10.1081/ADA-200037542
关键词
cocaine; cues; craving; fluoxetine; cortisol; adrenocortical
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000083] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [P50DA009253] Funding Source: NIH RePORTER
- NCRR NIH HHS [5-M01-RR00083] Funding Source: Medline
- NIDA NIH HHS [P50-DA09253] Funding Source: Medline
Preclinical data suggest a link between stress reactivity and cocaine self-administration by rodents. Serotonin appears to modulate the hypothalamic-pituitary -adrenal (HPA) axis. We studied the effects of chronic treatment with the scrotonin reuptake inhibitor fluoxetine 40 mg/day on subjective and hormonal responses to cocaine cues in 22 subjects participating in a controlled clinical trial for cocaine dependence. Fluoxetine antagonized the cue-induced increase in cortisol but increased subjects' ratings of the likelihood of cocaine use in response to cocaine cues. Cortisol response to cocaine cues was not related to subjective craving. Activation of the HPA axis by cocaine cues does not appear to be a necessary mediator of cue-induced craving.
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